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American Nobel laureate in medicine hopes to illuminate the brain
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Trump approves firing squad for convicted US military base shooter
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AI borrowing binge rattles US markets
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Grappling with 'homework scams,' US universities shun AI detectors
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Young Canadians sue government over alleged climate failures
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Separatists win Quebec election in test for Canada PM
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White Sox down Guardians to take 2-0 series lead
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Leaders visit Pacific atoll at frontline of climate change
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NHL record-breaker Ovechkin says current season will be his last
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Yemen's Houthis claim striking Riyadh airport, other Saudi sites
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France roar back in Nations League as Italy beat Turkey
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Best-selling British author Jeffrey Archer dies aged 86
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Messi readies for final farewell in Argentina send-off
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Military plane crash kills 32 in Nigeria
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Esposito seals Italy win over Turkey in Nations League
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Olise powers France to win over Belgium in Nations League
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Brazilian stocks surge to record after Bolsonaro election lead
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Milan's Saelemaekers suffers ankle setback, faces lengthy spell out
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ICC gives more details about arrest warrants for Taliban ministers
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Rubio arrives in Iceland to push for greater US presence in Arctic
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Nigeria's Tinubu confirms 32 dead after military plane crash
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Putin allows Italy's UniCredit to sell part of Russian business
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Bolsonaro rides right-wing surge into Brazil's election runoff
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Former Trump press secretary Leavitt joins Fox News
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Turkey blocks X account of British reporter
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Djokovic advances to China Open final as Medvedev out for hitting fan with ball
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Ukraine says using AI robot guns to shoot down new Russian drones
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Disgraced former US House speaker dies at 84
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At Oct 7 memorial, Netanyahu says will be no Hamas rule in Gaza
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Euro slides as worries about French debt grow
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Ukraine blames Russia for deadly sinking of Turkish ship in Black Sea
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US withdraws all bomber aircraft from UK airbase
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UN rights council slams Taliban's 'oppression' of women
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Drone hits Ethiopia IDP camp as fears grow of regional war
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Norway eyes partial ban of smart glasses
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US-German trio wins medicine Nobel for illuminating the brain
Purdy first 49er since Montana to throw five TDs as Colts beaten
Brock Purdy threw five touchdowns as the San Francisco 49ers all but ended the Indianapolis Colts' hopes of reaching the postseason with a 48-27 victory on Monday.
San Francisco quarterback Purdy finished with 295 passing yards from 25-of-34 attempts in a clinical exhibition at the Lucas Oil Stadium in Indianapolis.
Purdy's performance made him the first San Francisco quarterback to throw five touchdowns in a game since the legendary Joe Montana achieved the feat in 1990.
"It's an honor to be able to play for this organization with guys like Joe Montana and Steve Young and to be out here wearing the same uniform," Purdy told ESPN. "I'm just a kid living a dream."
The 49ers went into Monday's game safe in the knowledge that they had already clinched a playoff spot after results combined in their favor on Sunday.
But defeat for the Colts leaves them at 8-7 and needing a miraculous sequence of results in the final two weeks of the season if they are to reach the playoffs.
The Colts, with the 44-year-old Philip Rivers making his second appearance since his emergency call-up earlier this month, got off to a dream start with a touchdown on their opening drive when Rivers connected with Alec Pierce in the end zone.
Purdy then took over for the 49ers, finding Demarcus Robinson and Christian McCaffrey in quick succession to put the 49ers 14-7 ahead.
Although Rivers found Pierce again for a second touchdown to make it 14-14, Purdy led another touchdown drive for George Kittle to help San Francisco take a 24-17 lead at half-time.
San Francisco continued to keep the scoreboard ticking over in the second half, with Purdy tossing touchdowns to Jauan Jennings and McCaffrey to make it 41-27 midway through the fourth quarter.
An unhappy outing for Rivers ended with the Colts quarterback tossing an interception to the 49ers Dee Winters, who galloped into the end zone for San Francisco's sixth touchdown of the night.
J.Marty--VB