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American Nobel laureate in medicine hopes to illuminate the brain
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Tens of thousands expected in Paris for high school protests
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Trump approves firing squad for convicted US military base shooter
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AI borrowing binge rattles US markets
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Grappling with 'homework scams,' US universities shun AI detectors
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Young Canadians sue government over alleged climate failures
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Separatists win Quebec election in test for Canada PM
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White Sox down Guardians to take 2-0 series lead
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Leaders visit Pacific atoll at frontline of climate change
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NHL record-breaker Ovechkin says current season will be his last
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Yemen's Houthis claim striking Riyadh airport, other Saudi sites
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France roar back in Nations League as Italy beat Turkey
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Best-selling British author Jeffrey Archer dies aged 86
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Messi readies for final farewell in Argentina send-off
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Military plane crash kills 32 in Nigeria
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Esposito seals Italy win over Turkey in Nations League
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Olise powers France to win over Belgium in Nations League
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Russia downplays plague reports as Trump offers US help
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High-flying Blazy turns to birdlife at Chanel
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Trump says US moved bombers from UK base after 'threats'
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Riyadh's allies pledge troops as Yemen, Saudi Arabia attack Houthis
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Brazilian stocks surge to record after Bolsonaro election lead
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Clashes erupt outside Kosovo parliament over war crimes court
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Leaders to visit Pacific atoll at frontline of climate change
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Milan's Saelemaekers suffers ankle setback, faces lengthy spell out
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ICC gives more details about arrest warrants for Taliban ministers
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Rubio arrives in Iceland to push for greater US presence in Arctic
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Nigeria's Tinubu confirms 32 dead after military plane crash
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Putin allows Italy's UniCredit to sell part of Russian business
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'Reckless' AI firms can't control models, says whistleblower
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Djokovic into China Open final as Medvedev out for hitting fan with ball
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Switching on brain cells: the Nobel-winning science of optogenetics
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ICC unseals arrest warrants for Taliban education ministers
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Quebec votes as separatist surge poses test for Canada PM
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Modric hopes fans back Croatia against Spain after England shame
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Euro slides as concerns about French debt mount
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Bolsonaro rides right-wing surge into Brazil's election runoff
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Former Trump press secretary Leavitt joins Fox News
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Turkey blocks X account of British reporter
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Djokovic advances to China Open final as Medvedev out for hitting fan with ball
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Ukraine says using AI robot guns to shoot down new Russian drones
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Disgraced former US House speaker dies at 84
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At Oct 7 memorial, Netanyahu says will be no Hamas rule in Gaza
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Euro slides as worries about French debt grow
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Ukraine blames Russia for deadly sinking of Turkish ship in Black Sea
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US withdraws all bomber aircraft from UK airbase
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UN rights council slams Taliban's 'oppression' of women
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Drone hits Ethiopia IDP camp as fears grow of regional war
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Norway eyes partial ban of smart glasses
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US-German trio wins medicine Nobel for illuminating the brain
European stocks rise before rate cut, Wall Street mixed
European stock markets rose Wednesday on the eve of an expected interest-rate cut by the European Central Bank, but Wall Street was mixed as investors digested data that could influence the Federal Reserve's own monetary policy.
The Dow fell while the S&P 500 and tech-heavy Nasdaq rose in morning deals after payroll firm ADP said job gains in the US private sector slowed again in May, in a further sign that the world's top economy might be cooling.
Employers added 152,000 jobs last month due to a steep decline in manufacturing, down from a revised 188,000 figure in April and less than analysts anticipated, the report said.
Investors have been concerned that the US central bank will keep interest rates higher for longer, but a softer labour market could give the Fed more confidence to pivot to cuts sooner than feared.
While the Fed has yet to ease its monetary policy, the Canadian central bank decided Wednesday to slash its own rate to 4.75 percent.
In European markets, London, Paris and Frankfurt rose, with the ECB forecast to start cutting eurozone borrowing costs from historic highs on Thursday, although sticky inflation means the move is unlikely to kickstart a rapidly easing cycle.
"Thursday's ECB announcement is shaping up to be the main event this week," said Matthew Ryan, head of market strategy at global financial services firm Ebury.
"We think that a first 25-basis-point cut remains essentially guaranteed," he added.
"We expect the ECB to maintain its data-dependent approach and await confirmation of the downtrend in inflation before committing to additional cuts. This could lead to a relatively muted response in financial markets."
Asian indices closed lower as optimism that the Fed would cut interest rates before the end of the year was eclipsed by resurfacing fears over the health of the US economy.
Fears of persistent economic weakness have moved to the fore as a manufacturing index showed Monday that US activity contracted for a second successive month in May.
On Tuesday, official data showed job vacancies slipped to just under 8.1 million in April, 300,000 fewer than a month earlier, and well below market expectations.
That suggested a long-running period of high inflation and borrowing costs was taking its toll on the US economy.
The figures come ahead of closely watched non-farm payrolls figures due Friday, which will provide a much clearer snapshot for the US central bank ahead of its policy decision next week.
Readings below forecasts have for some time been taken as a positive, because they were seen as pointing to an economy still in good health but slowing enough to give the Fed room to start cutting rates -- known as a "Goldilocks" situation.
Bets on a Fed rate cut before the end of the year have picked up, with some eyeing September as the lift-off point.
Oil prices rose Wednesday after recent hefty losses, as investors continue to digest the OPEC+ alliance of major crude producers' decision to begin winding back output cuts from October and through next year.
- Key figures around 1400 GMT -
New York - Dow Jones: DOWN 0.3 at 38,597.08 points
New York - S&P 500: UP 0.2 percent at 5,303.37
New York - Nasdaq: UP 0.8 percent at 16,985.24
London - FTSE 100: UP 0.2 percent at 8,248.43
Paris - CAC 40: UP 0.9 percent at 8,005.69
Frankfurt - DAX: UP 0.8 percent at 18,543.98
EURO STOXX 50: UP 1.5 percent at 5,028.15
Tokyo - Nikkei 225: DOWN 0.9 percent at 38,490.17 (close)
Hong Kong - Hang Seng Index: DOWN 0.1 percent at 18,424.96 (close)
Shanghai - Composite: DOWN 0.1 percent at 3,087.56 (close)
Dollar/yen: UP at 156.22 yen from 154.88 yen on Tuesday
Euro/dollar: DOWN at $1.0873 from $1.0883
Pound/dollar: UP at $1.2773 from $1.2772
Euro/pound: DOWN at 85.12 pence from 85.19 pence
West Texas Intermediate: UP 0.4 percent at $73.53 per barrel
Brent North Sea Crude: UP 0.4 percent at $77.84 per barrel
burs-lth/rlp
A.Ruegg--VB