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American Nobel laureate in medicine hopes to illuminate the brain
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Tens of thousands expected in Paris for high school protests
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Trump approves firing squad for convicted US military base shooter
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AI borrowing binge rattles US markets
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Grappling with 'homework scams,' US universities shun AI detectors
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Young Canadians sue government over alleged climate failures
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Separatists win Quebec election in test for Canada PM
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White Sox down Guardians to take 2-0 series lead
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Leaders visit Pacific atoll at frontline of climate change
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NHL record-breaker Ovechkin says current season will be his last
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Yemen's Houthis claim striking Riyadh airport, other Saudi sites
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France roar back in Nations League as Italy beat Turkey
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Best-selling British author Jeffrey Archer dies aged 86
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Messi readies for final farewell in Argentina send-off
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Military plane crash kills 32 in Nigeria
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Esposito seals Italy win over Turkey in Nations League
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Olise powers France to win over Belgium in Nations League
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Russia downplays plague reports as Trump offers US help
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High-flying Blazy turns to birdlife at Chanel
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Trump says US moved bombers from UK base after 'threats'
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Riyadh's allies pledge troops as Yemen, Saudi Arabia attack Houthis
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Brazilian stocks surge to record after Bolsonaro election lead
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Clashes erupt outside Kosovo parliament over war crimes court
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Leaders to visit Pacific atoll at frontline of climate change
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Milan's Saelemaekers suffers ankle setback, faces lengthy spell out
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ICC gives more details about arrest warrants for Taliban ministers
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Rubio arrives in Iceland to push for greater US presence in Arctic
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Nigeria's Tinubu confirms 32 dead after military plane crash
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Putin allows Italy's UniCredit to sell part of Russian business
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'Reckless' AI firms can't control models, says whistleblower
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Djokovic into China Open final as Medvedev out for hitting fan with ball
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Switching on brain cells: the Nobel-winning science of optogenetics
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ICC unseals arrest warrants for Taliban education ministers
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Quebec votes as separatist surge poses test for Canada PM
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Modric hopes fans back Croatia against Spain after England shame
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Euro slides as concerns about French debt mount
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Bolsonaro rides right-wing surge into Brazil's election runoff
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Former Trump press secretary Leavitt joins Fox News
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Turkey blocks X account of British reporter
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Djokovic advances to China Open final as Medvedev out for hitting fan with ball
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Ukraine says using AI robot guns to shoot down new Russian drones
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Disgraced former US House speaker dies at 84
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At Oct 7 memorial, Netanyahu says will be no Hamas rule in Gaza
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Euro slides as worries about French debt grow
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Ukraine blames Russia for deadly sinking of Turkish ship in Black Sea
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US withdraws all bomber aircraft from UK airbase
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UN rights council slams Taliban's 'oppression' of women
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Drone hits Ethiopia IDP camp as fears grow of regional war
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Norway eyes partial ban of smart glasses
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US-German trio wins medicine Nobel for illuminating the brain
Asian markets mixed as focus turns to US inflation report
Asian markets wobbled Wednesday ahead of key US inflation data later in the day, with traders struggling to pick up the baton after a record performance on Wall Street.
A report showing a forecast-beating rise in April wholesale prices was offset by a downward revision for the previous month, while analysts said a deeper look at the figures suggested the Federal Reserve's preferred gauge of inflation could ease further.
Investors were also digesting a warning from the central bank's boss that the battle against prices was proving tougher than expected and indicated interest rates could remain elevated for some time.
There was also some nervousness on trading floors after Beijing hit out at Washington's decision to impose steep tariff hikes on Chinese imports such as electric vehicles and semiconductors.
The commerce ministry said the decision would "severely affect the atmosphere for bilateral cooperation".
But all focus is on the release later Wednesday of the consumer price index (CPI), which will likely play a key role in the Fed's decision on when to start cutting interest rates, if at all this year.
The report follows readings that came in above expectations in the first three months of the year, denting hopes for a reduction in borrowing costs.
However, the data is forecast to show prices slowing down again.
"Investors are expecting inflation to fall in April," Ameriprise's Anthony Saglimbene said.
"Even if the decline is slight, markets are looking for further evidence that the downward trend in inflation remains intact and, importantly, is not in the process of reversing course higher."
A sense of optimism on Wall Street pushed all three main indexes higher, with the Nasdaq hitting a new record and the S&P 500 coming within a whisker of its own all-time peak.
Asia was mixed, with Tokyo, Sydney, Taipei and Jakarta rising but Shanghai, Singapore, Wellington and Manila falling.
Hong Kong and Seoul were closed for holidays.
The CPI release comes after Fed chief Jerome Powell said readings at the start of the year had lowered his level of confidence that price rises would slow back down towards officials' long-term target.
"The first quarter in the United States was notable for its lack of further progress on inflation," he said. "We did not expect this to be a smooth road, but these were higher than I think anybody expected.
"And so what that has told us is we'll need to be patient and let restrictive policy do its work."
However, he added that he did not expect the Fed would need to hike rates.
Also Tuesday, Kansas City Fed chief Jeffrey Schmid warned rates could stay high "for some time" and that he was "prepared to be patient as this process plays out".
- Key figures around 0230 GMT -
Tokyo - Nikkei 225: UP 0.4 percent at 38,491.15 (break)
Shanghai - Composite: DOWN 0.4 percent at 3,134.82
Hong Kong - Hang Seng Index: Closed for a holiday
Dollar/yen: UP at 156.46 yen from 156.40 yen
Euro/dollar: UP at $1.0822 from $1.0819 on Monday
Pound/dollar: UP at $1.2592 from $1.2590
Euro/pound: UP at 85.95 from 85.92 pence
West Texas Intermediate: UP 0.7 percent at $78.59 per barrel
Brent North Sea Crude: UP 0.6 percent at $82.90 per barrel
New York - Dow: UP 0.3 percent at 39,558.11 (close)
London - FTSE 100: UP 0.2 percent at 8,428.13 (close)
-- Bloomberg News contributed to this story --
K.Hofmann--VB